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Cotrimoxazole and warfarin combination increases UGI tract haemorrhage risk

A study has suggested that cotrimoxazole may significantly increases the risk of upper gastrointestinal (UGI) tract haemorrhage among older patients taking warfarin.

The study, published in the Archives of Internal Medicine, evaluated the risk of UGI tract haemorrhage in older patients receiving warfarin in combination with antibiotics commonly used to treat urinary tract infections

They concluded that use of cotrimoxazole in patients receiving long-term warfarin therapy was associated with an almost 4-fold increase in the risk of hospitalisation for UGI tract haemorrhage, considerably higher than that with other antibiotics.

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