The labour ward at King George Hospital is to close as part of NHS plans to improve maternity services across north-east London.
NHS North East London and the City made the decision at its latest board meeting, with the changes set to come into force from March 18.
Pre and post natal services will still be provided at the hospital but women will no longer be able to give birth there.
The closure is a measure in a wide-ranging programme to ensure all local women get the safe, high-quality service they deserve at all local hospitals in the area.
Specialist services will be concentrated in fewer centres with more senior doctor cover as part of the changes, meaning women with more complex births will be able to deliver their babies more safely.
The NHS has also opened new midwife-led birthing centres in Barking and Queen’s Hospital Romford for lower risk pregnancies, providing greater choice and capacity for where women give birth.
Birthing capacity has also increased at Newham and Homerton Hospitals.
Local GPs and independent experts have given their support to the closure at King George Hospital as part of an assurance process designed to ensure that no changes are made to services until they have been assessed as safe for patients.