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Link found between high salt consumption and ageing

Obese teenagers who eat a lot of salty food may be getting old before their time, a US study suggests.

Scientists found evidence of their cells ageing more quickly than those of overweight teens who consumed less salt, or slimmer individuals.

In older people, the same genetic process has been linked to ailments of ageing such as heart disease, cancer, type 2 diabetes, and dementia.

The findings are based on a study of telomeres, protective caps on the ends of chromosomes that shorten as we age.

“High sodium intake and obesity may act synergistically to accelerate cellular ageing”

Haidong Zhu

Telomeres have been compared with the plastic tips that stop shoe laces fraying, or bomb fuses. When they get too short, cells become inactive or die.

Research has shown that the speed of telomere shortening can vary between individuals, corresponding to different rates of biological ageing.

High levels of body fat were already known to hasten the shortening of telomeres.

The new study found that sodium in salt seems to work hand-in-hand with obesity to speed the effect up still further.

Lead scientist Dr Haidong Zhu, from Georgia Regents University in Augusta, said: “Lowering sodium intake, especially if you are overweight or obese, may slow down the cellular ageing process that plays an important role in the development of heart disease.”

Haidong Zhu

Haidong Zhu

Dr Zhu’s team divided 766 teenagers aged 14 to 18 into different groups according to their reported sodium intake.

Low-intake teens consumed an average of just over two grams of sodium a day, compared with more than four grams for the high-intake group.

Both groups consumed far more than the daily maximum 1.5 grams of sodium recommended by the American Heart Association - equivalent to around two thirds of a teaspoon of table salt.

The scientists found that among overweight and obese teenagers, those with a high sodium intake had significantly shorter telomeres than those in the low intake category. This was after adjusting for a number of factors that influence telomere length.

But high sodium intake did not have a significant effect on telomere shortening in normal-weight individuals.

“Even in these relatively healthy young people, we can already see the effect of high sodium intake, suggesting that high sodium intake and obesity may act synergistically to accelerate cellular ageing,” said Dr Zhu.

“The majority of sodium in the diet comes from processed foods”

Haidong Zhu

The research, presented at an American Heart Association meeting in San Francisco, suggests a possible link with inflammation, said the scientists.

Inflammation is known to hasten telomere shortening and is linked to obesity. It also increases a person’s sensitivity to salt.

“Lowering sodium intake may be an easier first step than losing weight for overweight young people who want to lower their risk of heart disease,” Dr Zhu added.

“The majority of sodium in the diet comes from processed foods, so parents can help by cooking fresh meals more often and by offering fresh fruit rather than potato chips for a snack.”

  • Read the study abstract (page 98) presented at the American Heart Association meeting



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