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VOL: 101, ISSUE: 06, PAGE NO: 39

Generic/proprietary names


Generic/proprietary names
- Aspirin: Caprin, Nu-Seals Aspirin.



- Many compound analgesic preparations contain aspirin.



- Blocks pain impulses in the central nervous system, inhibits prostaglandin synthesis, causes peripheral vasodilation resulting in antipyretic properties, decreases platelet aggregation.



- Mild to moderate pain.



- Pyrexia.



- Secondary cerebrovascular or cardiovascular disease prevention.



- Age under 16 years.



- Breastfeeding.



- Previous peptic ulceration.



- Haemophilia.



- Hypersensitivity, including asthma, angioedema urticaria or rhinitis linked to aspirin or non-steroidal anti-inflammatory drugs (NSAIDs).



- Asthma.



- Allergic disease.



- Impaired liver or kidney function.



- Dehydration.



Side-effects are few and are mainly mild except for:



- A high incidence of gastro-intestinal irritation with slight asymptomatic blood loss;



- Bronchospasm;



- Increased bleeding time;



- Possible skin reactions in hypersensitive patients.



- Increased risk of bleeding with anticoagulants and selective serotonin re-uptake inhibitors (SSRIs).



- Decreased effects with high-dose antiacids and steroids.



- Possibility of increased side-effects with other NSAIDs.



- Increases the effects of warfarin, and other medication such as insulin, methotrexate and phenytoin.



- Nurse prescribers: oral only.



- Available as regular, coated, and extended-release tablets or capsules.



- Other preparations include chewable tablets, liquid form and dispersible tablets.



- Also available as a suppository.



Patient teaching
- Possible gastric irritation is limited by taking aspirin after food.



- Keep this medication in the container it came in, tightly closed, and out of reach of children.



- Store it at room temperature and away from excess heat and moisture (not in the bathroom).



- Store aspirin suppositories in a cool place or in a refrigerator.



- Take any missed doses as soon as you remember. But do not take a double dose to make up for a missed one.



- Do not break, crush, or chew extended-release tablets and do not open extended-release capsules. Swallow them whole.



- Always read the label of any over-the-counter medications to check for aspirin content.



- Restrict alcohol intake.



- Report any tinnitus, sweating or hyperventilation to the prescribing health care professional.



Nursing considerations
- For patients who have had oral or dental surgery or tonsillectomy in the last seven days avoid chewable or dispersible aspirin tablets, or aspirin in crushed tablets or gargles.



- Assess pain and/or pyrexia one hour before or after medication.



- In long-term therapy monitor renal and liver function and ototoxicity.



- Assess other medication for possible interactions - especially warfarin which is a special hazard.



- Be aware that aspirin is a common constituent of a variety of over-the-counter medications.



Nurses should refer to manufacturer’s summary of product characteristics and to appropriate local guidelines

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