VOL: 101, ISSUE: 06, PAGE NO: 39
- Aspirin: Caprin, Nu-Seals Aspirin.
- Many compound analgesic preparations contain aspirin.
- Blocks pain impulses in the central nervous system, inhibits prostaglandin synthesis, causes peripheral vasodilation resulting in antipyretic properties, decreases platelet aggregation.
- Mild to moderate pain.
- Secondary cerebrovascular or cardiovascular disease prevention.
- Age under 16 years.
- Previous peptic ulceration.
- Hypersensitivity, including asthma, angioedema urticaria or rhinitis linked to aspirin or non-steroidal anti-inflammatory drugs (NSAIDs).
- Allergic disease.
- Impaired liver or kidney function.
Side-effects are few and are mainly mild except for:
- A high incidence of gastro-intestinal irritation with slight asymptomatic blood loss;
- Increased bleeding time;
- Possible skin reactions in hypersensitive patients.
- Increased risk of bleeding with anticoagulants and selective serotonin re-uptake inhibitors (SSRIs).
- Decreased effects with high-dose antiacids and steroids.
- Possibility of increased side-effects with other NSAIDs.
- Increases the effects of warfarin, and other medication such as insulin, methotrexate and phenytoin.
- Nurse prescribers: oral only.
- Available as regular, coated, and extended-release tablets or capsules.
- Other preparations include chewable tablets, liquid form and dispersible tablets.
- Also available as a suppository.
- Possible gastric irritation is limited by taking aspirin after food.
- Keep this medication in the container it came in, tightly closed, and out of reach of children.
- Store it at room temperature and away from excess heat and moisture (not in the bathroom).
- Store aspirin suppositories in a cool place or in a refrigerator.
- Take any missed doses as soon as you remember. But do not take a double dose to make up for a missed one.
- Do not break, crush, or chew extended-release tablets and do not open extended-release capsules. Swallow them whole.
- Always read the label of any over-the-counter medications to check for aspirin content.
- Restrict alcohol intake.
- Report any tinnitus, sweating or hyperventilation to the prescribing health care professional.
- For patients who have had oral or dental surgery or tonsillectomy in the last seven days avoid chewable or dispersible aspirin tablets, or aspirin in crushed tablets or gargles.
- Assess pain and/or pyrexia one hour before or after medication.
- In long-term therapy monitor renal and liver function and ototoxicity.
- Assess other medication for possible interactions - especially warfarin which is a special hazard.
- Be aware that aspirin is a common constituent of a variety of over-the-counter medications.
Nurses should refer to manufacturer’s summary of product characteristics and to appropriate local guidelines