VOL: 101, ISSUE: 26, PAGE NO: 29
Generic and proprietary names
- Augmentin, Augmentin-Duo.
- An antibiotic that combines amoxicillin and clavulanic acid. It destroys bacteria by disrupting their ability to form cell walls.
- Clavulanic acid blocks the chemical defence, known as beta-lactamase, that some bacteria have against penicillins. l Co-amoxiclav is active against bacterial infections that have become resistant to amoxicillin.
- Broad-spectrum penicillin.
- Known or suspected amoxicillin-resistant infections including respiratory tract, skin and soft tissue, genitourinary, and ear, nose and throat infections.
- Effective against strains of Escherichia coli, Proteus mirabilis, Haemophilus influenzae, Streptococcus faecalis, Streptococcus pneumoniae and some beta-lactamase-producing organisms.
- Penicillin hypersensitivity.
- History of co-amoxiclav-associated or penicillin-associated jaundice or hepatic dysfunction.
- History of allergy.
- Renal impairment.
- Erythematous rashes common in glandular fever.
- Cytomegalovirus infection.
- Acute or chronic lymphocytic leukaemia.
- Hepatic impairment.
- Cholestatic jaundice.
- Cholestatic jaundice.
- Erythema multiforme (including Stevens-Johnson syndrome).
- Toxic epidermal necrolysis.
- Exfoliative dermatitis.
- Convulsions (especially in high doses or in renal impairment).
- Superficial teeth staining when using the suspension.
- Phlebitis at injection site.
- Prolonged bleeding.
- Oral: tablets and suspension.
- Intravenous injection.
- Assess bowel pattern before and during treatment as pseudomembranous colitis may occur.
- Report haematuria or oliguria as high doses can be nephrotoxic.
- Assess respiratory status.
- Observe for anaphylaxis.
- Ensure that the patient has adequate fluid intake during any diarrhoea attack.
- If the patient develops a rash, wheezing, itching, fever or swelling in the joints, this could indicate an allergy and should be reported.
- Patients must ensure they take the full course of the medicine.
- The medicine must be taken in equal doses around the clock to maintain level in the blood.
- If oral contraceptives are used, use alternative contraception.
- Report diarrhoea, cramping and blood in stools as pseudomembranous colitis may occur.
Nurses should refer to manufacturer’s summary of product characteristics and to appropriate local guidelines