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VOL: 101, ISSUE: 26, PAGE NO: 29

Generic and proprietary names


Generic and proprietary names
- Co-amoxiclav.



- Augmentin, Augmentin-Duo.



- An antibiotic that combines amoxicillin and clavulanic acid. It destroys bacteria by disrupting their ability to form cell walls.



- Clavulanic acid blocks the chemical defence, known as beta-lactamase, that some bacteria have against penicillins. l Co-amoxiclav is active against bacterial infections that have become resistant to amoxicillin.



- Broad-spectrum penicillin.



- Known or suspected amoxicillin-resistant infections including respiratory tract, skin and soft tissue, genitourinary, and ear, nose and throat infections.



- Effective against strains of Escherichia coli, Proteus mirabilis, Haemophilus influenzae, Streptococcus faecalis, Streptococcus pneumoniae and some beta-lactamase-producing organisms.



- Penicillin hypersensitivity.



- History of co-amoxiclav-associated or penicillin-associated jaundice or hepatic dysfunction.



- History of allergy.



- Renal impairment.



- Erythematous rashes common in glandular fever.



- Cytomegalovirus infection.



- Acute or chronic lymphocytic leukaemia.



- Hepatic impairment.



- Pregnancy.



- Cholestatic jaundice.



Common side-effects
- Hepatitis.



- Cholestatic jaundice.



- Erythema multiforme (including Stevens-Johnson syndrome).



- Toxic epidermal necrolysis.



- Exfoliative dermatitis.



- Vasculitis.



- Dizziness.



- Headache.



- Convulsions (especially in high doses or in renal impairment).



- Superficial teeth staining when using the suspension.



- Phlebitis at injection site.



Rare side-effects
- Prolonged bleeding.



- Oral: tablets and suspension.



- Intravenous injection.



Nursing considerations
- Assess bowel pattern before and during treatment as pseudomembranous colitis may occur.



- Report haematuria or oliguria as high doses can be nephrotoxic.



- Assess respiratory status.



- Observe for anaphylaxis.



- Ensure that the patient has adequate fluid intake during any diarrhoea attack.



Patient teaching
- If the patient develops a rash, wheezing, itching, fever or swelling in the joints, this could indicate an allergy and should be reported.



- Patients must ensure they take the full course of the medicine.



- The medicine must be taken in equal doses around the clock to maintain level in the blood.



- If oral contraceptives are used, use alternative contraception.



- Report diarrhoea, cramping and blood in stools as pseudomembranous colitis may occur.



Nurses should refer to manufacturer’s summary of product characteristics and to appropriate local guidelines

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