VOL: 102, ISSUE: 11, PAGE NO: 31
Generic and proprietary names
- Nexium: esomeprazole.
- Zoton: lansoprazole.
- Losec: omeprazole.
- Protium: pantoprazole.
- Pariet: rabeprazole.
- Combined preparations that include antibacterial medication are also available.
- The proton pump inhibitors inhibit the production of gastric acid by blocking the hydrogen-potassium adenosine triphosphate enzyme system of the gastric parietal cells.
- Gastrointestinal system: proton pump inhibitors.
- Liver disease.
- Symptoms of gastric cancer.
- Lansoprazole, omeprazole, pantoprazole and rabeprazole are licensed for the short-term treatment of benign duodenal and gastric ulcers.
- Proton pump inhibitors are used in conjunction with antibiotics for the eradication of Helicobacter pylori.
- Esomeprazole, lansoprazole and omeprazole are licensed for NSAID-associated peptic ulcers.
- A short course of proton pump inhibitors is the initial treatment in oesophageal reflux.
- Omeprazole is effective in the treatment of Zollinger-Ellison syndrome and acid reduction during general anaesthesia.
- Gastrointestinal upset.
Less common side-effects
- Dry mouth.
- Drowsiness, malaise.
- Blurred vision.
- Rashes, itching.
- The effects of phenytoin and warfarin are increased by some proton pump inhibitors.
- The absorption of the antifungal drugs ketoconazole and itraconazole is reduced by proton pump inhibitors.
- The breakdown of diazepam in the body may be blocked by some proton pump inhibitors so that it has an increased effect.
- Tablet, capsule, powder for suspension or injection.
- In combination with antibiotics, proton pump inhibitors are used to eradicate H. pylori infection, one of the main causes of recurring stomach ulcers.
- The differences between proton pump inhibitors in clinical efficacy and safety are considered to be minimal.
- Patients who require long-term symptom management should reduce their use of prescribed medication stepwise: using the lowest effective dose, then as required before returning to self-treatment with antacid and/or alginate therapy.
- Advise patients to avoid precipitants they associate with their dyspepsia such as smoking, alcohol, coffee or fatty foods.
- Overweight patients should be advised that weight reduction will help their condition.
- Other actions such as raising the head of the bed or not eating a main meal too close to going to bed may help some people.
Nurses should refer to manufacturer’s summary of product characteristics and to appropriate local guidelines