By continuing to use the site you agree to our Privacy & Cookies policy

Your browser seems to have cookies disabled. For the best experience of this website, please enable cookies in your browser.

Close

Your browser is no longer supported

For the best possible experience using our website we recommend you upgrade to a newer version or another browser.

Close

Proton pump inhibitors.

VOL: 102, ISSUE: 11, PAGE NO: 31

Generic and proprietary names

 

Generic and proprietary names
- Nexium: esomeprazole.

 

 

- Zoton: lansoprazole.

 

 

- Losec: omeprazole.

 

 

- Protium: pantoprazole.

 

 

- Pariet: rabeprazole.

 

 

- Combined preparations that include antibacterial medication are also available.

 

 

Action
- The proton pump inhibitors inhibit the production of gastric acid by blocking the hydrogen-potassium adenosine triphosphate enzyme system of the gastric parietal cells.

 

 

Classification
- Gastrointestinal system: proton pump inhibitors.

 

 

Cautions
- Liver disease.

 

 

- Pregnancy.

 

 

- Breastfeeding.

 

 

- Symptoms of gastric cancer.

 

 

Indications
- Lansoprazole, omeprazole, pantoprazole and rabeprazole are licensed for the short-term treatment of benign duodenal and gastric ulcers.

 

 

- Proton pump inhibitors are used in conjunction with antibiotics for the eradication of Helicobacter pylori.

 

 

- Esomeprazole, lansoprazole and omeprazole are licensed for NSAID-associated peptic ulcers.

 

 

- A short course of proton pump inhibitors is the initial treatment in oesophageal reflux.

 

 

- Omeprazole is effective in the treatment of Zollinger-Ellison syndrome and acid reduction during general anaesthesia.

 

 

Common side-effects
- Gastrointestinal upset.

 

 

- Headache.

 

 

- Dizziness.

 

 

Less common side-effects
- Dry mouth.

 

 

- Insomnia.

 

 

- Drowsiness, malaise.

 

 

- Blurred vision.

 

 

- Rashes, itching.

 

 

Interactions
- The effects of phenytoin and warfarin are increased by some proton pump inhibitors.

 

 

- The absorption of the antifungal drugs ketoconazole and itraconazole is reduced by proton pump inhibitors.

 

 

- The breakdown of diazepam in the body may be blocked by some proton pump inhibitors so that it has an increased effect.

 

 

Administration
- Tablet, capsule, powder for suspension or injection.

 

 

Nursing considerations
- In combination with antibiotics, proton pump inhibitors are used to eradicate H. pylori infection, one of the main causes of recurring stomach ulcers.

 

 

- The differences between proton pump inhibitors in clinical efficacy and safety are considered to be minimal.

 

 

- Patients who require long-term symptom management should reduce their use of prescribed medication stepwise: using the lowest effective dose, then as required before returning to self-treatment with antacid and/or alginate therapy.

 

 

Patient teaching
- Advise patients to avoid precipitants they associate with their dyspepsia such as smoking, alcohol, coffee or fatty foods.

 

 

- Overweight patients should be advised that weight reduction will help their condition.

 

 

- Other actions such as raising the head of the bed or not eating a main meal too close to going to bed may help some people.

 

 

Nurses should refer to manufacturer’s summary of product characteristics and to appropriate local guidelines

Have your say

You must sign in to make a comment.

Related Jobs

Sign in to see the latest jobs relevant to you!

newsletterpromo