The chief nurse at Mid Yorkshire Hospitals Trust has taken over the running of the organisation until the end of the last following the resignation of its chief executive.
Julia Squire resigned from the trust, which is facing a £20m year-end deficit, at the end of January after five years in post.
The trust announced she will be replaced in March by Stephen Eames, currently chief executive of County Durham and Darlington Foundation Trust.
Chief nurse and director of patient experience Tracey McErlain-Burns will act as interim chief executive until Mr Eames joins.
Mid Yorkshire has faced mounting finance and performance problems, and was recently told by an employment tribunal to pay £4.5m to a former staff member.
The trust is also struggling to staff emergency services and it was reported last month that it was considering using Army staff.