Your browser is no longer supported

For the best possible experience using our website we recommend you upgrade to a newer version or another browser.


Your browser appears to have cookies disabled. For the best experience of this website, please enable cookies in your browser

We'll assume we have your consent to use cookies, for example so you won't need to log in each time you visit our site.
Learn more

Biological key to motor neurone disease identified

  • Comment

A breakthrough in motor neurone disease research has come about after scientists identified a protein that recycles damaged proteins in motor nerves.

Approximately 5,000 people have the disease in the UK, which can be fatal within three years, and scientists have so far been unable to put their finger on what causes it.

However, the identification of the ubiquilin 2 protein is a major breakthrough for researchers as they say it is pivotal in recycling damaged or misshapen proteins in motor nerves.

Neurons rely on the efficient recycling of proteins in the cells to help them operate properly. But when this system breaks down, the nerve cells are unable to fix or maintain themselves and become severely damaged as a result.

The find may also be able to help scientists progress their research into other neurodegenerative conditions such as Parkinson’s and Alzheimer’s, according to the researchers writing in an early online edition of the journal Nature.

Lead researcher Professor Teepu Siddique, from Northwestern University in Chicago, said: “This opens up a whole new field for finding an effective treatment for ALS.”


  • Comment

Have your say

You must sign in to make a comment

Please remember that the submission of any material is governed by our Terms and Conditions and by submitting material you confirm your agreement to these Terms and Conditions. Links may be included in your comments but HTML is not permitted.

Related Jobs