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High clot risk for women admitted during pregnancy

Pregnant women admitted for reasons other than delivery have a higher risk of venous thromboembolism, according to a UK study published.

Researchers at Nottingham University and Guy’s and St Thomas’ Foundation Trust assessed VTE risk in hospitalised pregnant women, compared with rates outside hospital.

The study included 206,785 women aged 15-44, who had one or more pregnancies from1997 up to 2010.

Overall, the researchers found that hospitalisation during pregnancy was associated with an excess risk of 16.6 cases per 1,000 person-years compared with time outside hospital.

There was also an excess risk of 5.8 cases per 1,000 person years in the 28 days after discharge with VTE events more likely to occur in the third trimester of pregnancy and in women aged 35 years and over.

The authors said: “To our knowledge, this is the first study to assess the impact of antepartum hospitalisation on the incidence of VTE during pregnancy.”

Writing in the BMJ, they stated: “The overall risk of first venous thromboembolism in pregnant women increased during admissions to hospital not related to delivery, and remained significantly higher in the 28 days after discharge.

“During these periods need for thromboprophylaxis should receive careful consideration,” they added.

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