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C difficile bacteria 'may protect against food allergies'

Bacteria from a family that includes potentially deadly infectious bugs may protect against food allergies, research has shown.

Clostridia encompasses around 100 bacterial species, some of which live harmlessly in the gut.

Others are responsible for gangrene, tetanus, botulism food poisoning and hospital infections caused by Clostridium difficile.

The new study suggests that “friendly” Clostridia have a unique ability to block the harmful immune response behind food allergies.

“We’ve identified a bacterial population that protects against food allergen sensitisation”

Cathryn Nagler

Tests on “sterile” mice sensitised to peanuts showed that introducing a Clostridia cocktail into their bacteria-free guts reversed their allergy.

Re-introduction of another major group of gut bacteria, Bacteroides, did not have the same effect.

Tests indicated that Clostridia caused immune cells to produce high levels of a signalling molecule known to decrease permeability of the intestinal lining.

This in turn reduced the chances of allergens – molecules that trigger an allergic reaction – leaking into the bloodstream.

US lead scientist Professor Cathryn Nagler, from the University of Chicago, said: “We’ve identified a bacterial population that protects against food allergen sensitisation.

“The first step in getting sensitised to a food allergen is for it to get into your blood and be presented to your immune system. The presence of these bacteria regulates that process.”

University of Chicago

Cathryn Nagler

Environmental effects on gut flora – including over use of antibiotics, high-fat diets, excessive hygiene and even infant formula feeding – may be contributing to food allergies by suppressing Clostridia, the researchers believe.

Their findings appear in the journal Proceedings of the National Academy of Sciences.

Mice used in the study were either raised from birth in sterile conditions or treated with antibiotics as newborns to wipe out most of their gut bacteria.

Both groups were sensitised by exposing them to peanut allergens, triggering a strong immune response. They produced significantly higher levels of peanut-targeting antibodies than mice with normal populations of gut bacteria.

When Clostridia was present, immune cells generated high levels of the protective signalling molecule, interleukin 22 (IL-22). But when IL-22 was neutralised, levels of allergen in the animals’ bloodstreams significantly increased.

The team is now working on turning the discovery into a probiotic food allergy treatment, and has filed a provisional patent.

Bacteria 'may help food allergies'

“It’s exciting because we know what the bacteria are; we have a way to intervene,” said Professor Nagler. “There are of course no guarantees, but this is absolutely testable as a therapeutic against a disease for which there’s nothing.

Between 6% and 8% of children in the UK are believed to have a diagnosed food allergy.

Since 1990, the number of annual UK hospital admissions due to food allergy reactions has soared by 500%.

Severe food allergy can cause anaphylaxis, an extreme immune reaction that may prove fatal. Common triggers for anaphylaxis include peanuts, tree nuts such as almonds, walnuts and cashews, sesame, fish, shellfish, dairy products and eggs.

 

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