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Recurrent miscarriage and infertility increase pre-eclampsia risk

Recurrent miscarriage and infertility more than double the risk of pre-eclampsia, according to a study.

Researchers in Norway studied records of 20,846 singleton pregnancies in first-time mothers participating in the Norwegian Mother and Child Cohort Study (MoBa) between 1999 and 2005.

Findings showed women with recurrent miscarriages are 51% more likely to develop pre-eclampsia.

Women who had been treated for infertility had a 29% increased chance of developing pre-eclampsia.

When the two risk factors were combined, the chances of pre-eclampsia more than doubled, with an odds ratio of 2.4.

Authors wrote: ‘We have found an increased risk of pre-eclampsia in nulliparous women who have been treated for infertility.
‘The risk of pre-eclampsia appears to be especially increased in women who have both been treated for infertility and experienced recurrent miscarriage.’

British Journal of Obstetrics and Gynaecology (2009) 116:108-113

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