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Topical morphine not useful for arterial leg ulcer pain
Topical morphine is not clinically useful in relieving pain associated with arterial leg ulcers
This is the conclusion of a study that evaluated the effect of a topically applied hydrogel containing 0.5% morphine. The pilot study involving nine patients with painful arterial leg ulcers. The patients had assessed their pain to be at least 5 on a 10-point numeric rating scale.
They recieived three treatments in random order: morphine hydrogel and a subcutaneous (SC) placebo infusion; placebo gel and a SC infusion of 5mg morphine over six hours and a placebo gel plus a SC placebo infusion. Each treatment lasted one day.
The authors found that there was no difference in pain relief provided by each of the three treatments and suggest further research involving ulcers of different aetiology.
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