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Added kidney benefit from tight HbA1c control

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Intensive glucose control in type 2 diabetes patients can significantly reduce the risk of kidney damage, say international researchers.

They studied 11,140 patients, of which half received intensive glucose control – using a modified release version of the sulfonylurea gliclazide plus other drugs as required to achieve an HbA1c of 6.5% – and the rest received standard control.

After five years, researchers found those in the intensive control group were 21% less likely to suffer from new or worsening nephropathy compared to the control group, whose average HbA1c was 7.3%.

‘The clear reduction in nephropathy is important because indexes of renal impairment are strongly associated with the future risk of major vascular events, end-stage renal disease, and death in patients with diabetes,’ the authors said online in the New England Journal of Medicine.

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