A daily dose of aspirin could reduce organ damage, and may be of particular benefit to the millions of people who suffer alcohol abuse and obesity.
Wajahat Mehal from Yale School of Medicine said the drug may help prevent and treat liver damage from a number of non-infectious causes.
He added: "Many agents such as drugs and alcohol cause liver damage, and we have found two ways to block a central pathway responsible for such liver injury.
"Our strategy is to use aspirin on a daily basis to prevent liver injury."
According to Mr Mehal it has also given further hope to drugs which have previously failed clinical trials because of liver toxicity. If these are now combined with aspirin the results could be different.
He said: "This offers the exciting possibility of reducing a lot of pain and suffering in patients with liver diseases, using a new and very practical approach."
Recently professors also said women who take aspirin daily may slightly reduce their chance of developing breast cancer.