Pre-menopausal women who have both ovaries removed are more likely to die of all causes unless they receive additional oestrogen, a new study reports.
US researchers compared 1,097 women who had prophylactic bilateral oophorectomies - except for cancer -with 2,390 case matched controls who had not undergone oophorectomy.
Findings show women under 45 who had both ovaries removed were 67% more likely to die of all causes during the five years study than those in the control group, unless they had received oestrogen supplements.
The authors suggest that oestrogen protects pre-menopausal women against cardiovascular disease, osteoporosis and bone fracture and neurological disease.
Lancet Oncology(2006) 7:821-828