Your browser is no longer supported

For the best possible experience using our website we recommend you upgrade to a newer version or another browser.

Your browser appears to have cookies disabled. For the best experience of this website, please enable cookies in your browser

We'll assume we have your consent to use cookies, for example so you won't need to log in each time you visit our site.
Learn more


  • Comment

VOL: 101, ISSUE: 32, PAGE NO: 31

Generic and proprietary names

Generic and proprietary names
- Chlorphenamine.

- Piriton.

- Also present in many over-the-counter allergy, cough and decongestant preparations.

- Competes with histamine for H1 receptor sites and reduces allergic response by blocking histamine.

- Antihistamines.

- Sedating antihistamines.


- Relief of allergy symptoms such as hay fever, and urticaria.

- Emergency treatment of anaphylactic reactions in conjunction with adrenalin.

- Previous hypersensitivity.

- Prostatic hypertrophy.

- Urinary retention.

- Glaucoma.

- Pyloroduodenal obstruction.

- Hepatic disease.

- Renal impairment.

- Epilepsy.

Common side-effects
- Drowsiness.

- Headache.

- Psychomotor impairment.

- Urinary retention.

- Dry mouth.

- Blurred vision.

- Gastrointestinal problems.

Other side-effects
- Injection may cause transient hypotension or central nervous system (CNS) stimulation and may be irritant.

- Palpitations/arrythmias.

- Hypotension.

- Hypersensitivity reactions.

- Extrapyramidal effects.

- Dizziness and confusion.

- Sleep disturbances.

- Blood disorders.

- Liver dysfunction.

- Sedation increased by alcohol.

- Increased CNS depression with barbiturates, opiates, hypnotics and tricyclics.

- Monoamine oxidase inhibitors may increase side-effects.

- Increased anticholinergic action with atropine, quinidine, phenothiazine and haloperidol.

- Subcutaneous or intramuscular injection.

- Tablets.

- Syrup or oral solution.

Patient teaching
- Ensure patients are warned that this medication may cause drowsiness and that if they are affected they should not drive or operate machinery.

- Advise patients to avoid alcohol as this may increase the medication's sedative effects.

- Drowsiness may improve after a few days of treatment.

- In allergy management patients should also be advised to limit exposure to the allergen.

- Patients should be made aware that many over-the- counter medications may contain chlorphenamine.

- This medication can be safely stopped when symptoms have shown signs of improvement.

Nursing considerations
- Patients vary in their response to sedating antihistamines and there is little evidence that one is superior to another.

- Children and older people may be more susceptible to side-effects.

- Evaluate therapeutic response.

Nurses should refer to manufacturer's summary of product characteristics and to appropriate local guidelines

  • Comment

Have your say

You must sign in to make a comment

Please remember that the submission of any material is governed by our Terms and Conditions and by submitting material you confirm your agreement to these Terms and Conditions. Links may be included in your comments but HTML is not permitted.