VOL: 101, ISSUE: 32, PAGE NO: 31Generic and proprietary names
Generic and proprietary names
- Also present in many over-the-counter allergy, cough and decongestant preparations.
- Competes with histamine for H1 receptor sites and reduces allergic response by blocking histamine.
- Sedating antihistamines.
- Relief of allergy symptoms such as hay fever, and urticaria.
- Emergency treatment of anaphylactic reactions in conjunction with adrenalin.
- Previous hypersensitivity.
- Prostatic hypertrophy.
- Urinary retention.
- Pyloroduodenal obstruction.
- Hepatic disease.
- Renal impairment.
- Psychomotor impairment.
- Urinary retention.
- Dry mouth.
- Blurred vision.
- Gastrointestinal problems.
- Injection may cause transient hypotension or central nervous system (CNS) stimulation and may be irritant.
- Hypersensitivity reactions.
- Extrapyramidal effects.
- Dizziness and confusion.
- Sleep disturbances.
- Blood disorders.
- Liver dysfunction.
- Sedation increased by alcohol.
- Increased CNS depression with barbiturates, opiates, hypnotics and tricyclics.
- Monoamine oxidase inhibitors may increase side-effects.
- Increased anticholinergic action with atropine, quinidine, phenothiazine and haloperidol.
- Subcutaneous or intramuscular injection.
- Syrup or oral solution.
- Ensure patients are warned that this medication may cause drowsiness and that if they are affected they should not drive or operate machinery.
- Advise patients to avoid alcohol as this may increase the medication's sedative effects.
- Drowsiness may improve after a few days of treatment.
- In allergy management patients should also be advised to limit exposure to the allergen.
- Patients should be made aware that many over-the- counter medications may contain chlorphenamine.
- This medication can be safely stopped when symptoms have shown signs of improvement.
- Patients vary in their response to sedating antihistamines and there is little evidence that one is superior to another.
- Children and older people may be more susceptible to side-effects.
- Evaluate therapeutic response.
Nurses should refer to manufacturer's summary of product characteristics and to appropriate local guidelines