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VOL: 102, ISSUE: 03, PAGE NO: 41

Generic and proprietary names


Generic and proprietary names
- Goserelin.



- Zoladex.



- Zoladex LA.



- Continued administration results in pituitary desensitisation and the inhibition of gonadotrophin release.



- Drugs affecting gonadotrophins.



- Hormone antagonists.



- Cancer of the prostate.



- Early and advanced cancer of the breast.



- Endometriosis.



- Thinning of the endometrium before uterine surgery.



- Pituitary down-regulation prior to assisted conception.



- Pregnancy.



- Unexplained vaginal bleeding.



- Use for longer than six months or repeated use.



- Polycystic ovary disease.



- Metabolic bone disease.



Common side-effects
- Menopause-like symptoms.



- Decrease in bone density.



- Headache.



- Hypersensitivity.



- Sexual dysfunction.



Rare side-effects
- Palpitations.



- Hypertension.



- Change in breast size.



- Musculoskeletal problems.



- Visual disturbance.



- Weight change.



- Mood change.



- Ovarian cysts.



- Paraesthesia.



- Changes in scalp or body hair.



- Oedema of the face and extremities.



- Subcutaneous implant injection.



- Subcutaneous long-acting implant injection.



- Normal site for injections is the anterior abdominal wall.



Nursing considerations
- Pregnancy should be excluded before administration of this medication, therefore give first injection during or shortly after menstruation.



Patient teaching
- Ensure women are aware that goserelin may cause their menstrual cycle to become irregular or menstrual periods to cease.



- Barrier methods of contraception should be used to prevent pregnancy while on this medication.



- Women who suspect they are pregnant should seek immediate medical attention, as there is a risk of goserelin causing problems to the unborn baby.



Nurses should refer to manufacturer’s summary of product characteristics and to appropriate local guidelines

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