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Goserelin.

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VOL: 102, ISSUE: 03, PAGE NO: 41

Generic and proprietary names

 

Generic and proprietary names
- Goserelin.

 

 

- Zoladex.

 

 

- Zoladex LA.

 

 

Action
- Continued administration results in pituitary desensitisation and the inhibition of gonadotrophin release.

 

 

Classification
- Drugs affecting gonadotrophins.

 

 

- Hormone antagonists.

 

 

Indications
- Cancer of the prostate.

 

 

- Early and advanced cancer of the breast.

 

 

- Endometriosis.

 

 

- Thinning of the endometrium before uterine surgery.

 

 

- Pituitary down-regulation prior to assisted conception.

 

 

Contraindications
- Pregnancy.

 

 

- Unexplained vaginal bleeding.

 

 

- Use for longer than six months or repeated use.

 

 

Cautions
- Polycystic ovary disease.

 

 

- Metabolic bone disease.

 

 

Common side-effects
- Menopause-like symptoms.

 

 

- Decrease in bone density.

 

 

- Headache.

 

 

- Hypersensitivity.

 

 

- Sexual dysfunction.

 

 

Rare side-effects
- Palpitations.

 

 

- Hypertension.

 

 

- Change in breast size.

 

 

- Musculoskeletal problems.

 

 

- Visual disturbance.

 

 

- Weight change.

 

 

- Mood change.

 

 

- Ovarian cysts.

 

 

- Paraesthesia.

 

 

- Changes in scalp or body hair.

 

 

- Oedema of the face and extremities.

 

 

Administration
- Subcutaneous implant injection.

 

 

- Subcutaneous long-acting implant injection.

 

 

- Normal site for injections is the anterior abdominal wall.

 

 

Nursing considerations
- Pregnancy should be excluded before administration of this medication, therefore give first injection during or shortly after menstruation.

 

 

Patient teaching
- Ensure women are aware that goserelin may cause their menstrual cycle to become irregular or menstrual periods to cease.

 

 

- Barrier methods of contraception should be used to prevent pregnancy while on this medication.

 

 

- Women who suspect they are pregnant should seek immediate medical attention, as there is a risk of goserelin causing problems to the unborn baby.

 

 

Nurses should refer to manufacturer’s summary of product characteristics and to appropriate local guidelines

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