Your browser is no longer supported

For the best possible experience using our website we recommend you upgrade to a newer version or another browser.

Your browser appears to have cookies disabled. For the best experience of this website, please enable cookies in your browser

We'll assume we have your consent to use cookies, for example so you won't need to log in each time you visit our site.
Learn more

Genes can define treatment regimes for cardiovascular risk

  • Comment

Screening for a specific genetic variation can identify which patients are in greatest need of primary prevention for cardiovascular disease, US research suggests.

The importance of the common DNA variation in the 9p21 chromosomal was highlighted by researchers this week at an American Heart Association conference in New Orleans.

‘We already know that 9p21 DNA variation is associated with a greater risk of heart events, but now we have shown its direct usefulness to patient care by adding it to traditional risk factor measurements,’ said lead author Ariel Brautbar, clinical postdoctoral fellow in molecular and human genetics at Baylor College of Medicine in Houston

The researchers tested 10,000 middle-aged patients already taking part in study on the causes of atherosclerosis to identify those with a variation in 9p21. Subjects had already been categorised into high, intermediate and low risk – based on traditional cardiovascular risk factors.

However, the authors found that, based on the presence of the genetic variation, many of those who were found to have a higher risk than previously thought. As a result, nearly 20% in the low risk range and 16% in the intermediate risk range had to be recategorised.

‘A person at high risk will be treated aggressively, regardless of whether he or she has this variation. A low-risk person with good health won’t be treated differently either,’ Dr Brautbar said. ‘However, someone in the intermediate risk group could be moved into a higher or lower risk category, depending on whether he or she has the genetic variant. This, in turn, could affect how he or she is treated.’

  • Comment

Have your say

You must sign in to make a comment

Please remember that the submission of any material is governed by our Terms and Conditions and by submitting material you confirm your agreement to these Terms and Conditions. Links may be included in your comments but HTML is not permitted.

Related Jobs