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Investigating coronary heart disease in patients with angina

Coronary heart disease (CHD) is the leading cause of mortality and morbidity in the UK. The underlying disease is known as atherosclerosis, which has been described as a focal, inflammatory, fibro-proliferative response to multiple forms of endothelial injury (Ross, 1986). Its clinical consequences lead to myocardial ischaemia, resulting in angina and breathlessness and, if acute, may lead to myocardial infarction.

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