Men with heart disease who also have low testosterone levels are more likely to suffer a premature death, research suggests.
Experts from the Royal Hallamshire Hospital, Sheffield, said men with low levels of the hormone who have already been diagnosed with coronary heart disease are at a greater risk of dying early.
The group called for trials to be undertaken in a bid to identify any potential benefits of testosterone replacement therapy.
Writing in the journal Heart, they said: “In patients with coronary disease, testosterone deficiency is common and impacts significantly negatively on survival.
“Prospective trials of testosterone replacement are needed to assess the effect of treatment on survival.”
The study was carried out on more than 900 men with coronary heart disease. Almost a quarter (24%) of the group also had testosterone deficiency.
The men had been referred to a specialist heart centre between 2000 and 2002, and were tracked for around the next seven years.
Over the course of the study, almost twice as many men with low testosterone died as those with normal levels.
Overall, about one in five (21%) of those with low testosterone died, compared with one in eight (12%) of those with normal levels.