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Obesity triples risk of hardened arteries in diabetic children

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Obese diabetic children who are resistant to insulin are three times more likely to develop aetherothrombosis than those who are a healthy weight, according to research.

A study involving 313 obese children and adolescents found several factors linked to obesity that increased their likelihood of developing thromboses.

However, when found in insulin-resistant children, the levels of plasminogen activator inhibitor-1 (PAI-1) antigen and von Willebrand factor (vWF) antigen were found to triple this risk.

PAI-1 plays a part in preventing blood clots being broken down by the body, while vWF is a blood glycoprotein involved in haemostasis.

The Greek researchers suggested a link between this impaired prothrombotic state and an increased risk of developing cardiovascular disease in adulthood.

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