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Smoking activates COPD gene

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Some smokers have a genetic predisposition to developing COPD, according to a study.

Some smokers have a genetic predisposition to developing COPD, according to a study.

The study of 1,073 men over 40 who had smoked heavily for more than 20 years found 25% of them went on to develop COPD.

In those, COPD was linked with a genetic variance called -1112C/T, which only causes the condition in smokers.

‘The genetic variant we studied seemed harmless on its own,’ said Alireza Sadeghnejad, M.D., Ph.D., lead author. ‘But when someone has this variant, there is more of an adverse effect of smoking on lung function. Therefore, in combination with smoking, this genetic variant represents a risk factor for COPD.’

American Journal of Respiratory and Critical Care Medicine

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