There is wide variation in dose of fresh frozen plasma (FFP) use by ICU clinicians, according to UK researchers.
They warn that a high proportion of current FFP transfusions are of unproven clinical benefit.
The researchers carried out an eight week observational study in 29 adult ICUs, which included 1,923 admissions, of which 13% received FFP.
Overall, the median FFP dose was 10.8ml kg, but doses varied widely between 7.2 and 14.4ml kg.
The authors added that a “remarkably high proportion of FFP was administered to patients without evidence of bleeding”.
Critical Care (2011) 15: R108