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Cellular pathophysiology. Part 1: changes following tissue injury

Sharon Edwards, MSc, RN, DipN, PGCEA. Senior Lecturer, Department of Nursing and Midwifery, University of Hertfordshire The cellular changes that occur following an insult or hypoxic injury are common and an understanding of the underlying physiological principles of these changes is imperative. Once the initial insult has occurred, the neuroendocrine system and the inflammatory response (IR) are stimulated and endothelial damage initiates the clotting cascade.

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