Your browser is no longer supported

For the best possible experience using our website we recommend you upgrade to a newer version or another browser.

Your browser appears to have cookies disabled. For the best experience of this website, please enable cookies in your browser

We'll assume we have your consent to use cookies, for example so you won't need to log in each time you visit our site.
Learn more


  • Comment

VOL: 101, ISSUE: 26, PAGE NO: 29

Generic and proprietary names

- Co-amoxiclav.

- Augmentin, Augmentin-Duo.


- An antibiotic that combines amoxicillin and clavulanic acid. It destroys bacteria by disrupting their ability to form cell walls.

- Clavulanic acid blocks the chemical defence, known as beta-lactamase, that some bacteria have against penicillins. l Co-amoxiclav is active against bacterial infections that have become resistant to amoxicillin.


- Broad-spectrum penicillin.


- Known or suspected amoxicillin-resistant infections including respiratory tract, skin and soft tissue, genitourinary, and ear, nose and throat infections.

- Effective against strains of Escherichia coli, Proteus mirabilis, Haemophilus influenzae, Streptococcus faecalis, Streptococcus pneumoniae and some beta-lactamase-producing organisms.


- Penicillin hypersensitivity.

- History of co-amoxiclav-associated or penicillin-associated jaundice or hepatic dysfunction.


- History of allergy.

- Renal impairment.

- Erythematous rashes common in glandular fever.

- Cytomegalovirus infection.

- Acute or chronic lymphocytic leukaemia.

- Hepatic impairment.

- Pregnancy.

- Cholestatic jaundice.

Common side-effects

- Hepatitis.

- Cholestatic jaundice.

- Erythema multiforme (including Stevens-Johnson syndrome).

- Toxic epidermal necrolysis.

- Exfoliative dermatitis.

- Vasculitis.

- Dizziness.

- Headache.

- Convulsions (especially in high doses or in renal impairment).

- Superficial teeth staining when using the suspension.

- Phlebitis at injection site.

Rare side-effects

- Prolonged bleeding.


- Oral: tablets and suspension.

- Intravenous injection.

Nursing considerations

- Assess bowel pattern before and during treatment as pseudomembranous colitis may occur.

- Report haematuria or oliguria as high doses can be nephrotoxic.

- Assess respiratory status.

- Observe for anaphylaxis.

- Ensure that the patient has adequate fluid intake during any diarrhoea attack.

Patient teaching

- If the patient develops a rash, wheezing, itching, fever or swelling in the joints, this could indicate an allergy and should be reported.

- Patients must ensure they take the full course of the medicine.

- The medicine must be taken in equal doses around the clock to maintain level in the blood.

- If oral contraceptives are used, use alternative contraception.

- Report diarrhoea, cramping and blood in stools as pseudomembranous colitis may occur.

Nurses should refer to manufacturer’s summary of product characteristics and to appropriate local guidelines

  • Comment

Related files

Have your say

You must sign in to make a comment

Please remember that the submission of any material is governed by our Terms and Conditions and by submitting material you confirm your agreement to these Terms and Conditions. Links may be included in your comments but HTML is not permitted.