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Study suggests role in Alzheimer's disease treatment for curry spice

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An ingredient in the yellow curry spice turmeric may hold the key to repairing the brains of people with neurodegenerative diseases such as Alzheimer’s, German research suggests.

In laboratory tests, aromatic turmerone promoted the proliferation of brain stem cells and their development into neurons.

The bio-active compound could help scientists develop treatments for conditions in which brain cells are lost, including Alzheimer’s and stroke, it is claimed.

Lead researcher Dr Adele Rueger, from the Institute of Neuroscience and Medicine in Julich, said: “While several substances have been described to promote stem cell proliferation in the brain, fewer drugs additionally promote the differentiation of stem cells into neurons, which constitutes a major goal in regenerative medicine.

University of Cologne

Adele Rueger

“Our findings on aromatic turmerone take us one step closer to achieving this goal,” she said.

The scientists examined the effect of aromatic turmerone on endogenous neutral stem cells (NSCs) found within adult brains.

NSCs go on to develop into neurons, and play an important role in recovery from neurodegenerative diseases.

At certain concentrations, the turmeric compound boosted the proliferation of rat foetal NSCs by up to 80%, and increased the speed at which they matured.

“Our findings on aromatic turmerone take us one step closer to achieving this goal”

Adele Rueger

In living rats, injections of aromatic turmerone led to the expansion of two key brain regions, the subventricular zone (SVZ) and hippocampus.

Both are sites in adult mammalian brains where neurogenisis – the growth of new neurons – is known to occur.

The findings are published in the online journal Stem Cell Research & Therapy.

Aromatic turmerone is the lesser-studied of two major bio-active compounds in turmeric. The second, curcumin, is a well known anti-inflammatory agent and reputed to have anti-cancer properties.

 

 

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