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VOL: 101, ISSUE: 10, PAGE NO: 30

Generic/proprietary names


Generic/proprietary names
- Medroxyprogesterone acetate: Adgyn Medro, Depo-Provera, Farlutal, Provera.



- Medroxyprogesterone prevents follicular maturation and ovulation.



- Stimulates growth of mammary tissue.



- Antineoplastic action against endometrial cancer.



- Antineoplastic hormone contraceptive.



- Progesterone derivative.



- Contraception following appropriate counselling.



- Malignant disease.



- Dysfunctional uterine bleeding.



- Secondary amenorrhoea.



- Opposition of oestrogen in HRT.



- Mild to moderate endometriosis.



- Cancer of the breast or reproductive organs.



- Hypersensitivity.



- Severe liver impairment.



- Undiagnosed vaginal bleeding.



- Known or suspected pregnancy.



- Breastfeeding.



- Hypertension.



- Asthma.



- Diabetes.



- Epilepsy.



- Cardiac or renal dysfunction.



- A history of blood clots.



- Change to the menstrual cycle.



- Premenstrual-like syndrome.



- Weight gain.



- Nausea and vomiting.



- Headache.



- Dizziness.



- Insomnia.



- Depression.



- Skin reactions.



- Increases plasma ciclosporin concentration.



- Hormone antagonists reduce plasma concentration of medroxyprogesterone.



- For contraception the first injection should be given within five days after the beginning of a normal menstrual period, and repeated every 12 weeks.



- Oral preparations are tolerated better when taken with milk or food to reduce gastrointestinal side-effects.



- Confusion can arise with drugs of similar name - methylprednisolone and Premarin.



Nursing considerations
- Medroxyprogesterone should not be given for contraception without full counselling backed by the manufacturer’s approved leaflet.



- It can take 9-10 months to become pregnant after stopping medroxyprogesterone as a contraceptive.



- Heavy bleeding has been reported in women who start this contraceptive in the immediate puerperium. It is therefore better to delay giving the first injection until six weeks postnatally.



- Blood pressure should be recorded at the beginning of treatment and then periodically.



- The prescribing health care professional should be informed if weight gain is a problem.



- Monitor mental status.



- Evaluate therapeutic response.



Patient teaching
- When used for contraception lack of periods does not mean pregnancy when regular injections have been administered.



- If a contraceptive injection is late or missed, pregnancy can occur.



- Any unusual vaginal bleeding or breast lumps should be reported to the prescribing health care professional.



- Medroxyprogesterone does not provide protection against sexually transmitted diseases.



Nurses should refer to manufacturer’s summary of product characteristics and to appropriate local guidelines.

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