Using an octenidine based antiseptic to treat chronic venous leg ulcers is safer than Ringer’s solution, according to a study published online in the International Wound Journal.
The authors, including researchers from Cardiff University, compared octenidine dihydrochloride/phenoxyethanol (OHP) with a Ringer solution in 126 patients over 12 weeks.
The median time to complete ulcer healing using OHP was comparable, 92 days versus 87 for Ringer solution, regardless of wound size or duration of the target ulcer.
However, significantly fewer adverse events were observed with OHP, the authors said.
“OHP is well suitable for the treatment of chronic wounds without cytotoxic effects. Furthermore, OHP does not impair the wound healing in chronic venous ulcers,” they said.
- Vanscheidt, W., Harding, K., Téot, L. and Siebert, J. (2011), Effectiveness and tissue compatibility of a 12-week treatment of chronic venous leg ulcers with an octenidine based antiseptic - a randomized, double-blind controlled study. International Wound Journal. doi: 10.1111/j.1742-481X.2011.00886.x