COPD patients given inhaled corticosteroids are 70% more likely to be hospitalised for pneumonia than other patients with the condition, a study has shown.
Canadian researchers looked at175,906 patients with COPD over 15 years. Current use of inhaled corticosteroids was associated with a 70% increase in hospitalisation for pneumonia and a 53% increase in hospitalisation leading to death within 30 days, the authors said.
The rate of hospitalisation for pneumonia was greatest with the highest dose of inhaled corticosteroids -equivalent to fluticasone 1,000 mcg per day or more.
American Journal of Respiratory and Critical Care (2007) http://ajrccm.atsjournals.org