Your browser is no longer supported

For the best possible experience using our website we recommend you upgrade to a newer version or another browser.

Your browser appears to have cookies disabled. For the best experience of this website, please enable cookies in your browser

We'll assume we have your consent to use cookies, for example so you won't need to log in each time you visit our site.
Learn more

Diabetes drug reduces antipsychotic weight gain

  • Comment
A diabetes drug combined with lifestyle changes can help reduce the weight gain induced by atypical antipsychotic medications, research has shown.
According to the 12-week trial, metformin and an exercise and education programme were associated with a reduction in BMI, waist circumference and insulin resistance index.

The study group consisted of 128 adults with schizophrenia on atypical antipsychotic medications.

Those who gained more than 10% of their pre-treatment weight were assigned into four groups: a placebo group, a group who took metformin, a group who took metformin and physical exercise and a group who took exercise.

The metformin plus exercise group had an average BMI decrease of 1.8, insulin resistance index decrease of 3.6 and lost 2cms in waist circumference

Those on placebo group had a BMI increase of 1.2, insulin resistance index increase of 0.4 and waist circumference increases of 2.2.

Journal of the American Medical Association (2008) 299: 185-193
  • Comment

Have your say

You must sign in to make a comment

Please remember that the submission of any material is governed by our Terms and Conditions and by submitting material you confirm your agreement to these Terms and Conditions. Links may be included in your comments but HTML is not permitted.