There is no evidence that doubling the dose of inhaled corticosteroids at the onset of an asthma exacerbation reduces the need for rescue oral corticosteroids, contrary to common belief, a Cochrane Review has concluded.
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Researchers looked at five studies involving 28 children and 1,222 adults, taking an average 500mg daily dose of inhaled corticosteroids.
There was no evidence increasing this to 1,000mg reduced need for rescue therapy. The authors said: “The best approach is to prevent an exacerbation by ensuring regular use of inhaled corticosteroids.”