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Drug slows CKD progression

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Using benazepril in combination with amlodipine could slow chronic kidney disease (CKD) progression, according to international researchers.

Initial treatment for high blood pressure using the ACE inhibitor benazepril (Lotensin) plus the calcium channel blocker amlodipine should be considered instead of benazepril plus the diuretic hydrochlorothiazide, as it slows progression of chronic kidney disease to a greater extent.

The ACCOMPLISH trial, published online in The Lancet, involved 11,506 hypertension patients who were randomised to receive either regimen.

The researchers found 2 per cent of patients in the benazepril plus amlodipine group experienced CKD progression compared with 3.7 per cent in the benazepril plus hydrochlorothiazide group.

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