Researchers have warned that drugs used to tackle hospital-acquired infections (HAI) can increase the risk of post-operative complications.
The specific nature of different types of surgery should be taken into account before new antibiotic regimes are introduced, warned experts based at Addenbrooke’s Hospital in Cambridge.
Their study - which followed the introduction of new antibiotic regimes to combat HAIs such as C difficile - was published in the November issue of the British Journal of Urology International.
The team, led by Prof David Neal, found the risks associated with certain procedures increased significantly. For instance, patients undergoing a standard surgical procedure to diagnose prostate cancer developed more than five times as many infective complications when a new regime was introduced.
Prof Neal said proposed changes to antibiotic policies should be linked to strong clinical evidence because they “may potentially result in significant ill health and potential harm”.
- Madden T, et al. Infective complications after transrectal ultrasound-guided prostate biopsy following a new protocol for antibiotic prophylaxis aimed at reducing hospital-acquired infections. BJUI 2011; Advance online publication