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Epilepsy drug not effective against migraines

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The drug oxcarbazepine is not effective as a prophylactic treatment for migraine headaches, a study has shown.
Oxcarbazepine is currently widely used as a treatment for epilepsy and antiepileptic drugs have been used to treat migraine for five decades.

The aim of the study was to see if oxcarbazepine can be used to treat migraine, like other antiepileptic drugs like valproate, topiramate and gabapentin.

The study randomly divided a group of 170 patients into two cohorts of 85. One cohort was treated with titrations of oxcarbaxepine rising from 150mg/day to a maximum of 1,200 mg/day after five days. Patients in the second cohort were given a placebo treatment.

During the final 28 days of the 15-week trial, the number of migraine attacks was measured in both groups.

Results showed there was no difference between the oxcarbazepine group and the placebo group.

Neurology (2008) 70:548-555
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