Your browser is no longer supported

For the best possible experience using our website we recommend you upgrade to a newer version or another browser.

Your browser appears to have cookies disabled. For the best experience of this website, please enable cookies in your browser

We'll assume we have your consent to use cookies, for example so you won't need to log in each time you visit our site.
Learn more

Genetic defect could lead to improved eczema and allergy treatment

  • 1 Comment

Scientists have found a genetic defect in mice which leads to allergic inflammation similar to humans with eczema and related allergic diseases.

It is hoped the discovery of the mutations in the filaggrin gene could lead to better treatments for humans who suffer eczema and allergic reactions.

The filaggrin gene produces a protein in the outermost layers of skin, which helps form an impermeable barrier to keep the skin hydrated.

If the same skin barrier on humans is broken, allergens can enter the body where they produce a range of allergic responses such as eczema, asthma and hay fever.

The research, which is published on-line in the international journal Nature Genetics, found that a defect in the filaggrin gene leads to a break in the skin barrier making it more permeable to allergens and more prone to allergic skin inflammation.

The researchers, from the UK and Japan, said: ‘Drugs or other treatments aimed at the filaggrin gene are still some years away but this work is a major step in the right direction and should give hope to those with these distressing conditions.’

  • 1 Comment

Readers' comments (1)

  • You can also try probiotics! Our allergist said that about half of his patients who have eczema see improvement with probiotic use.

    Unsuitable or offensive? Report this comment

Have your say

You must sign in to make a comment

Please remember that the submission of any material is governed by our Terms and Conditions and by submitting material you confirm your agreement to these Terms and Conditions. Links may be included in your comments but HTML is not permitted.