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'High-dose anti-thrombotics cut death risk'

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Doubling the standard dose of anti-thrombotics can halve the risk of cardiovascular death in at-risk patients, a US study suggests.

Doubling the standard dose of anti-thrombotics can halve the risk of cardiovascular death in at-risk patients, a US study suggests.

Researchers found giving patients 600mg of clopidogrel before percutaneous coronary intervention, rather than the standard 300mg, halved the combined relative risk of heart attack and cardiac death.

The higher dose did not increase the risk of serious bleeding, the authors said at a meeting of the Society for Cardiovascular Angiography and Interventions in Florida.

They said: Â'This research has important clinical and cost implications.Â'

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