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Hip replacement success may be down to genes

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The reason why some people need to have their hip replacements resurfaced could be down to their genes, suggests UK research.

The reason why some people need to have their hip replacements resurfaced could be down to their genes, suggests UK research.

Variations in the genes responsible for generating an enzyme (MMP1) that breaks down collagen in bone and cartilage -a chemical involved in bone metabolismand vitamin D synthesis -were tested in 312 people.

Just over half had had problems in the decade after hip replacement surgery, including aseptic loosening, which occurs when the artificial joint comes loose and the surrounding bone starts to dissolve, and bacterial infection of the implants

Those with variations in the MMP1 gene were more than three times as likely to have aseptic loosening, while variations in the vitamin D receptor gene almost doubled the chances of bone dissolution and deep infection.

Annals of the Rheumatic Diseases (2007) ard.bmj.com

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