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Ibuprofen treatment slows CF onset

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Ibuprofen treatment can slow the rate of decline in lung function in children and adolescents with cystic fibrosis, a study has shown.
Patients who took high doses of ibuprofen had a 29% reduction in loss of lung function compared with those who did not use the drug over the study period of two to seven years.

The US study drew on data from children aged six to 17 who took doses of ibuprofen equivalent to 20 to 30 milligrams per kilogram of their weight.

Some patients took up to 1,600 milligrams per day – by comparison, over-the counter preparations advise a maximum daily dose of 1,200 milligrams for adults and children aged over 12.

Report author Dr Michael Konstan, of Rainbow Babies and Children’s Hospital, in Cleveland, Ohio, said: ‘The lung function of these patients declines over time, and rate of decline is associated with survival.

'Although we don’t have evidence to prove it, we would like to think that this slowing of lung function decline due to ibuprofen therapy translates into increased years of survival for patients with CF.’

American Journal of Respiratory and Critical Care Medicine (2007) 176: 1084-1089

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