People with low levels of LDL cholesterol face an increased risk of developing Parkinson's Disease, despite the benefits to their cardiovascular health, a new study shows.
The research may explain why smokers have a lower risk of developing Parkinson's Disease, since smoking boosts LDL-cholesterol levels.
Parkinson's patients are also known to be more likely to carry the APOE-2 gene, which is linked to low LDL cholesterol.
Researchers in the US recruited 124 patients with Parkinson's Disease attending a clinic and 112 healthy controls.
Subjects with lower LDL cholesterol levels (less than 114 milligrams per liter) were 3.5 times more likely to have Parkinson's than those with higher levels.
Movement Disorders (2007).Online publication. DOI:10.1002/mds.21290