It is currently unclear how many nursing posts are to go and Trafford Healthcare NHS Trust has made no decision on the wards that are to close.
But the trust says the changes, which will reduce the number of beds in the hospital by more than 30, are necessary to stave off the forecast deficit in April 2009.
It hopes to offer anyone affected alternative work, including retraining if necessary, a spokesperson said.
Chief executive Steve Spoerry said: “Our challenge in 2008 is to improve the care we provide for the people of Trafford whilst also achieving a financial surplus.”
Trafford General Hospital, one of the sites run by the trust was originally called Park Hospital and was the first to admit patients under the new NHS in 1948.