Desmopressin nasal sprays are no longer indicated for primary nocturnal enuresis (PNE).
Nasal forms have been linked with most of the serious adverse drug reactions reported in patients with PNE, according to the Medicines and Healthcare products Regulatory Agency. Rare, serious reactions reported have included hyponatraemia, water intoxication and convulsions.
The agency said patients may complete their current course of treatment with desmopressin nasal spray but at the next routine review should be prescribed an oral form.
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