Unison has called for action to be taken on the “shocking” report to be taken immediately.
Karen Jennings, the union’s head of health, said strong regulation must be introduced and that hospitals must be accountable to parliament.
“The clear lesson from this report is that public protection cannot be delivered by light touch regulation,” she said.
“A lack of regulation led to the banking crisis and it cannot work in a hospital with life or death situations. We need strong governance and accountability as part of the hospital’s recovery plan.”
Ms Jennings also criticised Monitor’s scrutiny of Mid Staffs as a foundation trust, and she said the problems might have been identified sooner if staff had been listened to.
“Staff are the barometer of how well a hospital is being run and managed,” she said.
“The hospital was ticking all the right boxes, but the staff were unhappy. This was never acted upon.”