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Paget's gene discovery could lead to screening test

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Scientists in Scotland have identified three genes that cause the majority of cases of the bone condition Paget’s disease, which could lead to a screening test.

They have identified three genes which account for 70% of cases of the painful bone condition Paget’s disease, a condition that affects up to one million people in the UK.

The three genes identified are all linked to bone repair.

And the researchers believe their findings go some way to explaining why sufferers of Paget’s disease have enlarged or malformed bones.

The study, reported in Nature Genetics, showed the three genes were more faulty in the 1,250 patients tested compared with healthy people.

The researchers said Paget’s disease normally runs in the family, and a screening test could help doctors treat the disease in its early stages.

Professor Stuart Ralston, who led the study, said a screening test was a strong possibility in the future because the effects of the genes were so powerful.

Click here to read the study in Nature Genetics

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