The rate of bowel cancer, also known as colorectal cancer, is rising across Europe among younger adults in the 20 to 49 age bracket, according to Dutch researchers, who called on clinicians to be “aware” of the trend.
Rates rose most steeply among the youngest age group, aged 20-29 years, and the study authors warn that if the trend continues, screening guidelines may need to be reconsidered.
“If the trend continues, screening guidelines may need to be reconsidered”
Rates tend to be lower among people over 50, but the opposite is true among younger adults in North America, Australia and China, said the researchers in the journal Gut.
They noted that, in the US, the increase in new cases among people aged 20-40 has prompted the American Cancer Society to recommend lowering the age at which to start screening to 45.
Over the past decade, the number of new cases of bowel cancer has risen in most European countries, but the situation on rates among younger adults is unclear, said the researchers.
As a result, they analysed data from national and regional cancer registries on the number of new cases and deaths related to bowel cancer between 1990 and 2016.
They used data from 143.7 million people aged 20-49 years from 20 countries, including Germany, Sweden, the UK and the Netherlands.
Between 1990 and 2016, a total of 187,918 people were diagnosed with bowel cancer and there was a steeper rise in the number of new cases in more recent years.
Among 20-29-year-olds, bowel cancer incidence rose from 0.8 to 2.3 cases per 100,000 people between 1990 and 2016, and the sharpest rise was between 2004 and 2016 at 7.9% per year.
For the 30-39-year-olds group, the incidence increased less steeply than the younger age group, at an average of 4.9% per year from 2005 to 2016, the researchers found.
Finally, among the 40-49 years age group, the bowel cancer rates fell by 0.8% between 1990-2004, but then increased slightly by 1.6% per year from 2004 to 2016.
New cases of bowel cancer rose significantly among people aged 20-39 in 12 countries – namely, Belgium, Germany, the Netherlands, the UK, Norway, Sweden, Finland, Ireland, France, Denmark, Czech Republic and Poland.
In eight countries – the UK, Greenland, Sweden, Slovenia, Germany, Finland, Denmark and the Netherlands – the number of cases rose significantly among 40-49-year-olds.
The number of deaths from bowel cancer did not significantly change in the 20-29 age group, but fell by 1.1% per year between 1990 and 2016 in the 30-39 group and by 2.4% per year between 1990 and 2009 among those aged 40-49.
The study authors said several factors may be behind these trends, including the rise in obesity, and lifestyle factors such as lack of physical activity, alcohol intake and smoking.
Bowel cancer in young adults is “in part due to hereditary cancer syndromes, but most cases are sporadic,” they added.
They said it was too early to use their findings to support lowering the screening age to 45 in Europe, but that screening guidelines may need to be reconsidered if the trend continued.
“Until the underlying cause of this trend is identified, it would be [a good idea] to raise clinicians’ awareness and identify factors possibly associated with this trend,” they said.
“Clinicians should be aware of this trend,” they said. “If the trend continues, screening guidelines may need to be reconsidered.”