There have been more than 2,000 pay-outs and the total bill is now £180m, following a review by the health ombudsman in 2003.
The DH has said that there may be more compensation claims to come from a further 1,300 reviews due to be complete by March.
A DH spokesperson said: 'The NHS has paid restitution to the affected individuals or their
families, totalling £180m to date.
'It is not possible to estimate the level of restitution that will be paid following the review of the remaining cases.
'This retrospective review process has brought about much greater understanding and improved process within the NHS."