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No link between sex hormones and prostate cancer

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There is no link between sex hormones in the bloodstream and prostate cancer, according to a study.
The Oxford University research pooled data from 18 previous studies, incorporating 3,886 men with incident prostate cancer and 6,438 controls.

Researchers divided subjects into five groups according to serum hormone levels and calculated risk of prostate cancer occurring.

They found no statistical likelihood of those with high serum concentrations of testosterone, dihydrotestosterone, dehydroepiandrosterone sulfate, androstenedione,
androstanediol glucuronide, and estradiol and prostate cancer.

Authors write: 'The study obliges the scientific community to move past a seductive, clinically relevant, and biologically plausible hypothesis and get on with the difficult task of exploring, analyzing, and characterizing modifiable risk factors for prostate cancer.'

Journal of the National Cancer Institute (2008) 100: 170-183
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