Common antibiotics, such as penicillin, may be best first-line treatment for children with MRSA-related infections, according to US researchers.
In a study of around 600 children, penicillin and other antibiotics in the beta-lactam family worked as well as other antibiotics – clindamycin or trimethoprim-sulfamethoxazole – to treat MRSA-related infections in the skin and soft tissue of children.
In fact the beta-lactam antibiotics were superior to the trimethoprim-sulfamethoxazole combination.
The authors said: ‘Compared with beta-lactams, clindamycin monotherapy conferred no benefit, whereas trimethoprim-sulfamethoxazole was associated with an increased risk of treatment failure.
‘Even in regions with endemic community-acquired MRSA, beta-lactams may still be appropriate, first-line, empiric therapy for children presenting with these infections,’ they added.