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PPIs may not increase risk of Clostridium difficile

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Proton pump inhibitors do not boost the chances of hospital admission with illness associated with Clostridium difficile, reveals a Canadian study.

Proton pump inhibitors do not boost the chances of hospital admission with illness associated with Clostridium difficile, reveals a Canadian study.

The research team analysed hospital records between 2002 and 2005 for the state of Ontario and found almost 1,400 patients who had been admitted with C difficile associated illness within 60 days of having been prescribed antibiotics.

Each of these cases was matched with 10 other people of the same age and sex who had also been prescribed antibiotics.

Results show that admitted with C.difficile are no more likely t to have been prescribed a PPIwithin the preceding three months, nor were they more likely to have been admitted to hospital than teh comparison group.

Clinical Infectious Diseases (2006) 43: 1272-6

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