A dose of glucose solution given to young children immediately before vaccination reduces pain, according to a study by nurses at the University of Sydney and Jordan University of Science and Technology.
Researchers randomised 120 infants aged two months to receive either 2mL of 25% oral glucose solution immediately prior to routine immunisation or 2mL of oral sterile water.
The primary outcome measured was behavioural pain measured using the Modified Behavioural Pain Scale. Secondary outcomes were crying time and duration of full-lung cry. Crying was registered from onset of the immunisation injection and for up to 120 seconds after completion of the injection procedure.
The authors said: “Infants in the intervention group experienced statistically and clinically significant reduction in behavioural pain responses, and spent less time crying up to two minutes after the procedure.”
The mean difference in crying was 38 seconds for those who recieved the glucose solution versus 77.9 seconds in those who did not.
“A 2 mL oral dose of 25% glucose given immediately before an immunisation procedure reduces pain in two-month old infants,” the authors added.
- Kassab, M et al (2011) A double-blind randomised controlled trial of 25% oral glucose for pain relief in 2-month old infants undergoing immunisation. International Journal of Nursing Studies 2012. Published online 17 October 2011.