Your browser is no longer supported

For the best possible experience using our website we recommend you upgrade to a newer version or another browser.

Your browser appears to have cookies disabled. For the best experience of this website, please enable cookies in your browser

We'll assume we have your consent to use cookies, for example so you won't need to log in each time you visit our site.
Learn more

High stress levels 'can make women infertile'

  • Comment

Too much stress can lead to infertility in women, a study has shown for the first time.

High levels of pre-conception stress more than double the chances of a woman failing to get pregnant after 12 months of trying, US scientists found.

A year of not conceiving, despite regular unprotected intercourse, is the clinical definition of infertility.

Previous research had already highlighted an association between high stress levels and a reduced probability of pregnancy.

The new findings, linking stress to infertility, are published in the latest online edition of the journal Human Reproduction.

Scientists measured levels of alpha-amylase, an enzyme in saliva that provides a biological indicator of stress.

Women with high levels of the biomarker were 29% less likely to get pregnant each month than those with low levels, the researchers found. They were also more than twice as likely to be declared infertile.

“For the first time, we’ve shown that this effect is potentially clinically meaningful”

Courtney Denning-Johnson Lynch

Study leader Dr Courtney Denning-Johnson Lynch, from Ohio State University, said: “This is now the second study in which we have demonstrated that women with high levels of the stress biomarker salivary alpha-amylase have a lower probability of becoming pregnant, compared to women with low levels of this biomarker.

“For the first time, we’ve shown that this effect is potentially clinically meaningful, as it’s associated with a greater than two-fold increased risk of infertility among these women.”

Dr Courtney Denning-Johnson Lynch

Courtney Denning-Johnson Lynch

The team tracked 373 American women aged 18 to 40 who were free from known fertility problems and had just started trying to conceive.

Their progress was followed over a period of 12 months, or until they became pregnant.

Each participant was given one saliva test on enrolment and another after the start of their first recorded menstrual cycle.

Measurements of two stress markers, alpha-amylase and cortisol, were taken.

Dr Lynch urged women having difficulty getting pregnant to consider stress-managing techniques, such as yoga and meditation.

However, she pointed out that stress is not the only factor involved in fertility problems and may only play a minor role.

“Eliminating stressors before trying might shorten the time couples need to become pregnant”

Germaine Buck Louis

Co-author Dr Germaine Buck Louis, from the Eunice Kennedy Shriver National Institute of Child Health and Human Development in Rockville, said: “Eliminating stressors before trying to become pregnant might shorten the time couples need to become pregnant in comparison to ignoring stress.

“The good news is that women most likely will know which stress reduction strategy works best for them, since a one-size-fits-all solution is not likely.”

  • Comment

Have your say

You must sign in to make a comment

Please remember that the submission of any material is governed by our Terms and Conditions and by submitting material you confirm your agreement to these Terms and Conditions. Links may be included in your comments but HTML is not permitted.